h-CD es una proteína reguladora de la contracción celular que se encuentra en el músculo liso y en las células mioepiteliales. Interactúa con la actina, la miosina, la tropomiosina y la calmodulina. Su detección permite identificar tumores de partes blandas con diferenciación de células de músculo liso como leiomiomas, angioleiomiomas, leiomiosarcomas y tumores glómicos.

En parénquima mamario se ha demostrado expresión de h-CD en las células mioepiteliales que rodean ductos y lóbulos, siendo negativa en las células epiteliales y los tumores derivados de estas, así como en los miofibroblastos. Es útil junto a otros anticuerpos (SMA, P63,…) en el diagnóstico diferencial entre carcinoma intraductal e infiltrante.

 

 

 

 

BIBLIOGRAFÍA

 

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01-2015 / M. Verdú