Epidermal growth factor receptor copy number variations, but not EGFR or KRAS mutations, are frequent in lung squamous cell carcinomas
R Roman1, N Rodon1, M Verdu1,3, B Garcia1 , M Pujol1, M. Calvo 4 and X Puig 1,2,3.
1BIOPAT.Biopatologia Molecular, SL, Grup Assistencia, Barcelona, Spain; 2Hospital de Barcelona, SCIAS, Grup Assistencia, Barcelona, Spain; 3Histopat Laboratoris, Barcelona, Spain and 4Statistics Department, Universitat Barcelona, Barcelona, Spain.
Background: Epidermal growth factor receptor (EGFR) mutations, and to a lesser extent EGFR copy number variations, have been correlated with response to EGFR tyrosine kinase inhibitors (TKIs). In contrast, KRAS mutations have been recently associated with resistance to […]