A. Colomer, N. Erill, M. Verdú, R. Román, A Vidal, X. Puig.

BIOPAT. Biopatologia Molecular, SL. Barcelona, Spain.

LOH 17p/TP53 and LOH 18q/DCC have been related to prognosis of colorectal adenocarcinomas. Since MSI-H tumors have a minor rate of TP53 mutations and rarely present allelic deletions, we intended to study these molecular features in a series of 197 primary tumors previously categorized for MSI status. Eighteen tumors out of 181 (10%) exhibited MSI-H. p53 alterations were approached by a combination of […]

Anna Colomer¹, Nadina Erill¹, Montse Verdú², Ruth Román¹, August Vidal^1,2, Xavier Puig^1,2.

¹BIOPAT, Biopatologia Molecular, Barcelona, Spain. ²Histopat Laboratoris, Barcelona, Spain.

Two different patterns have been described for colorectal tumorigenesis. The main one -affecting 85% of sporadic tumors- is based on the familial adenomatous polyposis (FAP) model, a multistep process that involves at least APC, K-RAS, DCC andTP53 genes. The second pathway shares its etiology with hereditary non-polyposis colorectal cancer (HNPCC), and is characterized by mutations at the mismatch repair genes (MMR) that lead […]