Publicaciones archivos - Página 14 de 20

Multicentric validation of a model based on phenotypic features to predict microsatellite instability in colorectal adenocarcinoma

R ROMAN¹, M VERDU^1,3, A VIDAL^3,5, M CALVO⁴, X SANJUAN⁵, M JIMENO⁶, A SALAS⁷, J AUTONELL⁸, I TRIAS⁹, N RODON¹, M GONZALEZ¹, B GARCIA¹ and X PUIG^1,2,3.

¹BIOPAT.Biopatologia Molecular, Barcelona, Spain; ²Hospital de Barcelona, Barcelona, Spain; ³Histopat Laboratoris, Barcelona, Spain; ⁴Statistics Department, Universitat de Barcelona, Barcelona, Spain; ⁵Hospital Universitari de Bellvitge, Barcelona, Spain; ⁶Hospital del Mar, Barcelona, Spain; ⁷Hospital Mútua de Terrassa, Terrasa, Spain; ⁸Hospital General de Vic, Vic, Spain and ⁹Hospital Plató, Barcelona, Spain.

Background: High microsatellite instability (MSI-H) allows the […]

Alberto 2009-03-23T17:17:26+00:00

Ki-67 and P16INK4A immunoexpression strongly correlates with increasing grade of CIN and HPV infection

Montse Verdú ^1,3, Ruth Roman¹^, Carme Pubill³, Miquel Calvo ⁴, August Vidal ^1,3 Beatriz García^1, Marta González¹, Natalia Rodón¹ and Xavier Puig^1,2,3.

¹BIOPAT. Biopatologia Molecular, SL, Grup Assistència; ²Hospital de Barcelona SCIAS, Grup Assistència; ³Histopat Laboratoris and ⁴Statistics Department, Universitat de Barcelona. Barcelona, Spain.

Background: MIB-1 immunoquantitative features have been correlated with the grade of dysplasia in cervical epithelium, while P16 accumulation has been related to the presence of high grade intraepithelial lesions (HSIL) and detection of human papillomavirus (HPV). The aim […]

Alberto 2008-05-23T17:57:38+00:00

Colo-rectal micropapillary carcinoma: a clinicopathological and molecular study of 27 cases

Ruth Roman¹, Montse Verdú ^1,3, August Vidal ^1,3, Miquel Calvo ⁴, Natalia Rodón¹, Beatriz García¹, Marta González¹ and Xavier Puig^1,2,3.

¹BIOPAT. Biopatologia Molecular, SL, Grup Assistencia; ²Hospital de Barcelona SCIAS, Grup Assistència; ³Histopat Laboratoris and ⁴Statistics Department, Universitat de Barcelona. Barcelona, Spain.

INTRODUCTION: Invasive micropapillary carcinoma (MC) is associated with frequent lymph node metastasis and adverse clinical outcome. It has been reported in ovary, breast, urinary bladder, ureter, lung, parotid gland and, recently, in colon. Little is known about the morphological and […]

Alberto 2008-05-23T17:13:35+00:00

A polymorphism in HDM2 (SNP309) associates with early onset in superficial tumors, TP53 mutations, and poor outcome in invasive bladder cancer

Sanchez-Carbayo M, Socci ND, Kirchoff T, Erill N, Offit K, Bochner BH and Cordon-Cardo C.

Division of Molecular Pathology, Computational Biology Center, and Departments of Medicine and Urology, Memorial Sloan-Kettering Cancer Center, New York, New York; Centro Nacional de Investigaciones Oncológicas, Madrid, Spain; and BIOPAT, Grup Assistencia, Barcelona, Spain

Abstract

Purpose: The HDM2 gene represents one of the central nodes in the p53 pathway. A recent study reported the association of a single nucleotide polymorphism (SNP309) in the HDM2 promoter region with accelerated […]

Alberto 2007-06-01T12:48:34+00:00

Topoisomerase II-Alpha gene copy number alterations in ERBB2-Positive primary breast carcinomas: A fluorescence in situ hybridization study

A Colomer¹, N Erill¹, M Górriz^1,2, M Verdú², R Roman¹, R Ibáñez¹, C Cordon-Cardo¹ and X Puig^1,2.

^{1BIOPAT. Biopatologia Molecular, SL, Grup Assistència, Barcelona, Spain and 2 Histopat Laboratoris, Barcelona, Spain.}

Background: Topoisomerase II-alpha gene (TOP2A) aberrations have been recently pointed as predictive markers of anthracycline-based adjuvant chemotherapy in breast cancer. While coamplification of ERBB2 and TOP2A seems to define a subgroup of high-risk patients likely to benefit from anthracycline treatment, the significance of a patient having TOP2A deletions in […]

Alberto 2007-03-23T17:36:46+00:00

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